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Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at Its Apex

The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the immune response. Here, we investigate how functio...

詳細記述

保存先:
書誌詳細
出版年:J Virol
主要な著者: Gift, Syna Kuriakose, Leaman, Daniel P., Zhang, Lei, Kim, Arthur S., Zwick, Michael B.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709597/
https://ncbi.nlm.nih.gov/pubmed/28978711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01216-17
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