Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at Its Apex

The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the immune response. Here, we investigate how functio...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Gift, Syna Kuriakose, Leaman, Daniel P., Zhang, Lei, Kim, Arthur S., Zwick, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709597/
https://ncbi.nlm.nih.gov/pubmed/28978711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01216-17
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