Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates

Host cell-mediated proteolytic cleavage of the human immunodeficiency virus type 1 (HIV-1) gp160 precursor glycoprotein into gp120 and gp41 subunits is required to generate fusion-competent envelope glycoprotein (Env) spikes. The gp120-directed broadly neutralizing monoclonal antibodies (bNabs) isol...

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Main Authors: Chakrabarti, Bimal K., Feng, Yu, Sharma, Shailendra Kumar, McKee, Krisha, Karlsson Hedestam, Gunilla B., LaBranche, Celia C., Montefiori, David C., Mascola, John R., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838230/
https://ncbi.nlm.nih.gov/pubmed/24067980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01247-13
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