A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex

The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is the sole target of broadly neutralizing antibodies (bnAbs). Several mechanisms, such as the acquisition of mutations, variability of the loop length, and alterations in the glycan pattern, are employed by the virus to...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Mishra, Nitesh, Sharma, Shaifali, Dobhal, Ayushman, Kumar, Sanjeev, Chawla, Himanshi, Singh, Ravinder, Das, Bimal Kumar, Kabra, Sushil Kumar, Lodha, Rakesh, Luthra, Kalpana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2020
Konular:
Genetic Diversity and Evolution
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495384/
https://ncbi.nlm.nih.gov/pubmed/32669335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00814-20
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