A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex

The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is the sole target of broadly neutralizing antibodies (bnAbs). Several mechanisms, such as the acquisition of mutations, variability of the loop length, and alterations in the glycan pattern, are employed by the virus to...

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Bibliografiske detaljer
Udgivet i:	J Virol
Main Authors:	Mishra, Nitesh, Sharma, Shaifali, Dobhal, Ayushman, Kumar, Sanjeev, Chawla, Himanshi, Singh, Ravinder, Das, Bimal Kumar, Kabra, Sushil Kumar, Lodha, Rakesh, Luthra, Kalpana
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology 2020
Fag:	Genetic Diversity and Evolution
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7495384/ https://ncbi.nlm.nih.gov/pubmed/32669335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00814-20
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A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex

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