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Molecular Origins of APOBEC-Associated Mutations in Cancer

The APOBEC family of cytidine deaminases has been proposed to represent a major enzymatic source of mutations in cancer. Here, we summarize available evidence that links APOBEC deaminases to cancer mutagenesis. We also highlight newly identified human cell models of APOBEC mutagenesis, including can...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Petljak, Mia, Maciejowski, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494591/
https://ncbi.nlm.nih.gov/pubmed/32818816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102905
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