Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

High rates of APOBEC-signature mutations are found in many tumors, but factors affecting this mutation pattern are not well understood. Here, we explored the contribution of two common germline variants in the APOBEC3 region. A single nucleotide polymorphism, rs1014971, was associated with bladder c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Middlebrooks, Candace D., Banday, A. Rouf, Matsuda, Koichi, Udquim, Krizia-Ivana, Onabajo, Olusegun O., Paquin, Ashley, Figueroa, Jonine D., Zhu, Bin, Koutros, Stella, Kubo, Michiaki, Shuin, Taro, Freedman, Neal D., Kogevinas, Manolis, Malats, Nuria, Chanock, Stephen J., Garcia-Closas, Montserrat, Silverman, Debra T., Rothman, Nathaniel, Prokunina-Olsson, Ludmila
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583788/
https://ncbi.nlm.nih.gov/pubmed/27643540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3670
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados