Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

High rates of APOBEC-signature mutations are found in many tumors, but factors affecting this mutation pattern are not well understood. Here, we explored the contribution of two common germline variants in the APOBEC3 region. A single nucleotide polymorphism, rs1014971, was associated with bladder c...

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Pubblicato in:Nat Genet
Autori principali: Middlebrooks, Candace D., Banday, A. Rouf, Matsuda, Koichi, Udquim, Krizia-Ivana, Onabajo, Olusegun O., Paquin, Ashley, Figueroa, Jonine D., Zhu, Bin, Koutros, Stella, Kubo, Michiaki, Shuin, Taro, Freedman, Neal D., Kogevinas, Manolis, Malats, Nuria, Chanock, Stephen J., Garcia-Closas, Montserrat, Silverman, Debra T., Rothman, Nathaniel, Prokunina-Olsson, Ludmila
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583788/
https://ncbi.nlm.nih.gov/pubmed/27643540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3670
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