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Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis. Identification of factors affecting the activity of these enzymes could help modulate mutagenesis and associated clinical outcomes. Here, we show that canonical and alternatively spliced A3A and A3B isoforms produce corresp...
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| Vydáno v: | Commun Biol |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7985488/ https://ncbi.nlm.nih.gov/pubmed/33753867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01844-5 |
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