Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis. Identification of factors affecting the activity of these enzymes could help modulate mutagenesis and associated clinical outcomes. Here, we show that canonical and alternatively spliced A3A and A3B isoforms produce corresp...

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Udgivet i:Commun Biol
Main Authors: Rouf Banday, A., Onabajo, Olusegun O., Lin, Seraph Han-Yin, Obajemu, Adeola, Vargas, Joselin M., Delviks-Frankenberry, Krista A., Lamy, Philippe, Bayanjargal, Ariunaa, Zettelmeyer, Clara, Florez-Vargas, Oscar, Pathak, Vinay K., Dyrskjøt, Lars, Prokunina-Olsson, Ludmila
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985488/
https://ncbi.nlm.nih.gov/pubmed/33753867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01844-5
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