Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4(+) and CD8(+) T cell and neutralizing antibody responses...

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Pubblicato in:Cell
Autori principali: Rydyznski Moderbacher, Carolyn, Ramirez, Sydney I., Dan, Jennifer M., Grifoni, Alba, Hastie, Kathryn M., Weiskopf, Daniela, Belanger, Simon, Abbott, Robert K., Kim, Christina, Choi, Jinyong, Kato, Yu, Crotty, Eleanor G., Kim, Cheryl, Rawlings, Stephen A., Mateus, Jose, Tse, Long Ping Victor, Frazier, April, Baric, Ralph, Peters, Bjoern, Greenbaum, Jason, Ollmann Saphire, Erica, Smith, Davey M., Sette, Alessandro, Crotty, Shane
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494270/
https://ncbi.nlm.nih.gov/pubmed/33010815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.038
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