Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophrenia Increases Developmental Vulnerability to TNFα

Schizophrenia (SZ) is a neurodevelopmental genetic disorder in which maternal immune activation (MIA) and increased tumor necrosis factor-α (TNF-α) may contribute. Previous studies using iPSC-derived cerebral organoids and neuronal cells demonstrated developmental malformation and transcriptional dy...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Benson, Courtney A., Powell, Hana R., Liput, Michal, Dinham, Siddhartha, Freedman, David A., Ignatowski, Tracey A., Stachowiak, Ewa K., Stachowiak, Michal K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cellular Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484483/
https://ncbi.nlm.nih.gov/pubmed/33005129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00233
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