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Antinociception occurs with a reversal in α(2)-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory
Tumor necrosis factor-α (TNF) plays a role in neuropathic pain. During neuropathic pain development in the chronic constriction injury model, elevated TNF levels in the brain occur in association with enhanced α(2)-adrenoceptor inhibition of norepinephrine release. α(2)-Adrenoceptors are also locate...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587399/ https://ncbi.nlm.nih.gov/pubmed/18514187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.04.043 |
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