Antinociception occurs with a reversal in α(2)-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory

Tumor necrosis factor-α (TNF) plays a role in neuropathic pain. During neuropathic pain development in the chronic constriction injury model, elevated TNF levels in the brain occur in association with enhanced α(2)-adrenoceptor inhibition of norepinephrine release. α(2)-Adrenoceptors are also locate...

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Hlavní autoři: Sud, Reeteka, Spengler, Robert N., Nader, Nader D., Ignatowski, Tracey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587399/
https://ncbi.nlm.nih.gov/pubmed/18514187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.04.043
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