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Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1
Aldehyde dehydrogenase 9A1 (ALDH9A1) is a human enzyme that catalyzes the NAD(+)-dependent oxidation of the carnitine precursor 4-trimethylaminobutyraldehyde to 4-N-trimethylaminobutyrate. Here we show that the broad-spectrum ALDH inhibitor diethylaminobenzaldehyde (DEAB) reversibly inhibits ALDH9A1...
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| Publicado no: | Arch Biochem Biophys |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484307/ https://ncbi.nlm.nih.gov/pubmed/32717224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2020.108477 |
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