Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors

The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is essential in lipid A biosynthesis and has emerged as a promising target for the development of novel antibiotics against multidrug-resistant Gram-negative pathogens. Recently, we reported the crystal structure of Klebsiella pneumoniae Lpx...

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Vydáno v:Bioorg Chem
Hlavní autoři: Kwak, Seung-Hwa, Cochrane, C. Skyler, Ennis, Amanda F., Lim, Won Young, Webster, Caroline G., Cho, Jae, Fenton, Benjamin A., Zhou, Pei, Hong, Jiyong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484203/
https://ncbi.nlm.nih.gov/pubmed/32663666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.104055
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