Structure–Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay

The UDP-2,3-diacylglucosamine pyrophosphatase LpxH in the Raetz pathway of lipid A biosynthesis is an essential enzyme in the vast majority of Gram-negative pathogens and an excellent novel antibiotic target. The (32)P-radioautographic thin-layer chromatography assay has been widely used for analysi...

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Pubblicato in:ACS Infect Dis
Autori principali: Lee, Minhee, Zhao, Jinshi, Kwak, Seung-Hwa, Cho, Jae, Lee, Myungju, Gillespie, Robert A., Kwon, Do-Yeon, Lee, Hyunji, Park, Hyun-Ju, Wu, Qinglin, Zhou, Pei, Hong, Jiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730544/
https://ncbi.nlm.nih.gov/pubmed/30721024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00364
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