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Structure–Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay
The UDP-2,3-diacylglucosamine pyrophosphatase LpxH in the Raetz pathway of lipid A biosynthesis is an essential enzyme in the vast majority of Gram-negative pathogens and an excellent novel antibiotic target. The (32)P-radioautographic thin-layer chromatography assay has been widely used for analysi...
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| Publicat a: | ACS Infect Dis |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6730544/ https://ncbi.nlm.nih.gov/pubmed/30721024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00364 |
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