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Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors
The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is essential in lipid A biosynthesis and has emerged as a promising target for the development of novel antibiotics against multidrug-resistant Gram-negative pathogens. Recently, we reported the crystal structure of Klebsiella pneumoniae Lpx...
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| Veröffentlicht in: | Bioorg Chem |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484203/ https://ncbi.nlm.nih.gov/pubmed/32663666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.104055 |
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