The UDP-diacylglucosamine Pyrophosphohydrolase LpxH in Lipid A Biosynthesis Utilizes Mn(2+) Cluster for Catalysis

In Escherichia coli and the majority of β- and γ-proteobacteria, the fourth step of lipid A biosynthesis, i.e. cleavage of the pyrophosphate group of UDP-2,3-diacyl-GlcN, is carried out by LpxH. LpxH has been previously suggested to contain signature motifs found in the calcineurin-like phosphoester...

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Bibliographic Details
Main Authors: Young, Hayley E., Donohue, Matthew P., Smirnova, Tatyana I., Smirnov, Alex I., Zhou, Pei
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779701/
https://ncbi.nlm.nih.gov/pubmed/23897835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497636
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