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The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release

Gram-negative bacteria are surrounded by a secondary membrane of which the outer leaflet is composed of the glycolipid lipopolysaccharide (LPS), which guards against hydrophobic toxins, including many antibiotics. Therefore, LPS synthesis in bacteria is an attractive target for antibiotic developmen...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Bohl, Thomas E., Ieong, Pek, Lee, John K., Lee, Thomas, Kankanala, Jayakanth, Shi, Ke, Demir, Özlem, Kurahashi, Kayo, Amaro, Rommie E., Wang, Zhengqiang, Aihara, Hideki
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971466/
https://ncbi.nlm.nih.gov/pubmed/29626094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002503
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