Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus

In response to respiratory insults, airway submucosal glands secrete copious mucus strands to increase mucociliary clearance and protect the lung. However, in cystic fibrosis, stimulating submucosal glands has the opposite effect, disrupting mucociliary transport. In CF pigs, loss of CFTR anion chan...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Xie, Yuliang, Lu, Lin, Tang, Xiao Xiao, Moninger, Thomas O., Huang, Tony Jun, Stoltz, David A., Welsh, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484121/
https://ncbi.nlm.nih.gov/pubmed/32730755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.07.002
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