Impaired Mucus Detachment Disrupts Mucociliary Transport in a Piglet Model of Cystic Fibrosis

Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that predisposes airways to bacterial infection. People with advanced CF exhibit deficits in mucociliary transport (MCT), a process that traps and propels bacteria out of lungs, but whether this occurs first or i...

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Pubblicato in:Science
Autori principali: Hoegger, Mark J., Fischer, Anthony J., McMenimen, James D., Ostedgaard, Lynda S., Tucker, Alex J., Awadalla, Maged A., Moninger, Thomas O., Michalski, Andrew S., Hoffman, Eric A., Zabner, Joseph, Stoltz, David A., Welsh, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346163/
https://ncbi.nlm.nih.gov/pubmed/25124441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1255825
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