Pharmacoproteomics identifies kinase pathways that drive the epithelial-mesenchymal transition and drug resistance in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a complex and deadly disease lacking druggable genetic mutations. The limited efficacy of systemic treatments for advanced HCC implies that predictive biomarkers and drug targets are urgently needed. Most HCC drugs target protein kinases and their kinase-dependent s...

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Vydáno v:Cell Syst
Hlavní autoři: Golkowski, Martin, Lau, Ho-Tak, Chan, Marina, Kenerson, Heidi, Vidadala, Venkata Narayana, Shoemaker, Anna, Maly, Dustin J., Yeung, Raymond S., Gujral, Taranjit S., Ong, Shao-En
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484106/
https://ncbi.nlm.nih.gov/pubmed/32755597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.07.006
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