Pharmacoproteomics identifies kinase pathways that drive the epithelial-mesenchymal transition and drug resistance in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a complex and deadly disease lacking druggable genetic mutations. The limited efficacy of systemic treatments for advanced HCC implies that predictive biomarkers and drug targets are urgently needed. Most HCC drugs target protein kinases and their kinase-dependent s...

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Bibliographic Details
Published in:Cell Syst
Main Authors: Golkowski, Martin, Lau, Ho-Tak, Chan, Marina, Kenerson, Heidi, Vidadala, Venkata Narayana, Shoemaker, Anna, Maly, Dustin J., Yeung, Raymond S., Gujral, Taranjit S., Ong, Shao-En
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484106/
https://ncbi.nlm.nih.gov/pubmed/32755597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.07.006
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