Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine-limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitive conditions is poorly understood. Here, we demonstr...

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Publicat a:Cancer Discov
Autors principals: Ngo, Bryan, Kim, Eugenie, Osorio-Vasquez, Victoria, Doll, Sophia, Bustraan, Sophia, Liang, Roger J., Luengo, Alba, Davidson, Shawn M., Ali, Ahmed, Ferraro, Gino B., Fischer, Grant M., Eskandari, Roozbeh, Kang, Diane S., Ni, Jing, Plasger, Ariana, Rajasekhar, Vinagolu K., Kastenhuber, Edward R., Bacha, Sarah, Sriram, Roshan K., Stein, Benjamin D., Bakhoum, Samuel F., Snuderl, Matija, Cotzia, Paolo, Healey, John H., Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Sabatini, David M., Jones, Drew R., Yu, Min, Zhao, Jean J., Jain, Rakesh K., Keshari, Kayvan R., Davies, Michael A., Vander Heiden, Matthew G., Hernando, Eva, Mann, Matthias, Cantley, Lewis C., Pacold, Michael E.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483776/
https://ncbi.nlm.nih.gov/pubmed/32571778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1228
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