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Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair

p53-binding protein 1 (53BP1) exerts distinct impacts in different situations involving DNA double-strand break (DSB) rejoining. Here we focus on how 53BP1 impacts upon the repair of ionising radiation-induced DSBs (IR-DSBs) and how it interfaces with Ku, the DNA end-binding component of canonical n...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Radiat Res
Egile Nagusiak: Shibata, Atsushi, Jeggo, Penny A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482155/
https://ncbi.nlm.nih.gov/pubmed/32779701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rraa053
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