Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling

Many clinical and preclinical studies report higher prevalence and severity of chronic pain in females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE(2) as a second stimulus as a model for pain chronicity. Intraplantar IL-6 induced hypersensitivity was similar in magnitude a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Paige, Candler, Barba-Escobedo, Priscilla A., Mecklenburg, Jennifer, Patil, Mayur, Goffin, Vincent, Grattan, David R., Dussor, Gregory, Akopian, Armen N., Price, Theodore J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2020
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480243/
https://ncbi.nlm.nih.gov/pubmed/32801151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1499-20.2020
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