Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling

Many clinical and preclinical studies report higher prevalence and severity of chronic pain in females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE(2) as a second stimulus as a model for pain chronicity. Intraplantar IL-6 induced hypersensitivity was similar in magnitude a...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Paige, Candler, Barba-Escobedo, Priscilla A., Mecklenburg, Jennifer, Patil, Mayur, Goffin, Vincent, Grattan, David R., Dussor, Gregory, Akopian, Armen N., Price, Theodore J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480243/
https://ncbi.nlm.nih.gov/pubmed/32801151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1499-20.2020
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