Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling

Many clinical and preclinical studies report higher prevalence and severity of chronic pain in females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE(2) as a second stimulus as a model for pain chronicity. Intraplantar IL-6 induced hypersensitivity was similar in magnitude a...

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Vydáno v:J Neurosci
Hlavní autoři: Paige, Candler, Barba-Escobedo, Priscilla A., Mecklenburg, Jennifer, Patil, Mayur, Goffin, Vincent, Grattan, David R., Dussor, Gregory, Akopian, Armen N., Price, Theodore J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480243/
https://ncbi.nlm.nih.gov/pubmed/32801151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1499-20.2020
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