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Spinal inhibition of P2XR or p38 signaling disrupts hyperalgesic priming in male, but not female, mice

Recent studies have demonstrated sexual dimorphisms in the mechanisms contributing to the development of chronic pain. Here we tested the hypothesis that microglia might preferentially regulate hyperalgesic priming in male mice. We based this hypothesis on evidence that microglia preferentially cont...

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Publié dans:Neuroscience
Auteurs principaux: Paige, Candler, Maruthy, Gayathri Batchalli, Mejia, Galo, Dussor, Gregory, Price, Theodore
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127868/
https://ncbi.nlm.nih.gov/pubmed/29913243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2018.06.012
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