AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma

The phosphatidylinositide-3 kinases and the downstream mediator AKT drive survival and proliferation of multiple myeloma (MM) cells. AKT signaling is active in MM and has pleiotropic effects; however, the key molecular aspects of AKT dependency in MM are not fully clear. Among the various downstream...

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Bibliografiska uppgifter
I publikationen:Blood Adv
Huvudupphovsmän: Bloedjes, Timon A., de Wilde, Guus, Maas, Chiel, Eldering, Eric, Bende, Richard J., van Noesel, Carel J. M., Pals, Steven T., Spaargaren, Marcel, Guikema, Jeroen E. J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2020
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479958/
https://ncbi.nlm.nih.gov/pubmed/32898245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001393
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