NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

In developing lymphocytes, expression and activity of the recombination activation gene protein 1 (RAG1) and RAG2 endonuclease complex is tightly regulated to ensure ordered recombination of the immunoglobulin genes and to avoid genomic instability. Aberrant RAG activity has been implicated in the g...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ochodnicka-Mackovicova, Katarina, Bahjat, Mahnoush, Bloedjes, Timon A., Maas, Chiel, de Bruin, Alexander M., Bende, Richard J., van Noesel, Carel J. M., Guikema, Jeroen E. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671331/
https://ncbi.nlm.nih.gov/pubmed/26153519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-621623
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