Layilin augments integrin activation to promote antitumor immunity

Tumor-infiltrating CD8(+) T cells mediate antitumor immune responses. However, the mechanisms by which T cells remain poised to kill cancer cells despite expressing high levels of inhibitory receptors are unknown. Here, we report that layilin, a C-type lectin domain–containing membrane glycoprotein,...

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發表在:J Exp Med
Main Authors: Mahuron, Kelly M., Moreau, Joshua M., Glasgow, Jeff E., Boda, Devi P., Pauli, Mariela L., Gouirand, Victoire, Panjabi, Luv, Grewal, Robby, Luber, Jacob M., Mathur, Anubhav N., Feldman, Renny M., Shifrut, Eric, Mehta, Pooja, Lowe, Margaret M., Alvarado, Michael D., Marson, Alexander, Singer, Meromit, Wells, Jim, Jupp, Ray, Daud, Adil I., Rosenblum, Michael D.
格式: Artigo
語言:Inglês
出版: Rockefeller University Press 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478725/
https://ncbi.nlm.nih.gov/pubmed/32539073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192080
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