Layilin augments integrin activation to promote antitumor immunity

Tumor-infiltrating CD8(+) T cells mediate antitumor immune responses. However, the mechanisms by which T cells remain poised to kill cancer cells despite expressing high levels of inhibitory receptors are unknown. Here, we report that layilin, a C-type lectin domain–containing membrane glycoprotein,...

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Publicado en:J Exp Med
Autores principales: Mahuron, Kelly M., Moreau, Joshua M., Glasgow, Jeff E., Boda, Devi P., Pauli, Mariela L., Gouirand, Victoire, Panjabi, Luv, Grewal, Robby, Luber, Jacob M., Mathur, Anubhav N., Feldman, Renny M., Shifrut, Eric, Mehta, Pooja, Lowe, Margaret M., Alvarado, Michael D., Marson, Alexander, Singer, Meromit, Wells, Jim, Jupp, Ray, Daud, Adil I., Rosenblum, Michael D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478725/
https://ncbi.nlm.nih.gov/pubmed/32539073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192080
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