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Layilin augments integrin activation to promote antitumor immunity

Tumor-infiltrating CD8(+) T cells mediate antitumor immune responses. However, the mechanisms by which T cells remain poised to kill cancer cells despite expressing high levels of inhibitory receptors are unknown. Here, we report that layilin, a C-type lectin domain–containing membrane glycoprotein,...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Mahuron, Kelly M., Moreau, Joshua M., Glasgow, Jeff E., Boda, Devi P., Pauli, Mariela L., Gouirand, Victoire, Panjabi, Luv, Grewal, Robby, Luber, Jacob M., Mathur, Anubhav N., Feldman, Renny M., Shifrut, Eric, Mehta, Pooja, Lowe, Margaret M., Alvarado, Michael D., Marson, Alexander, Singer, Meromit, Wells, Jim, Jupp, Ray, Daud, Adil I., Rosenblum, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478725/
https://ncbi.nlm.nih.gov/pubmed/32539073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192080
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