Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Traditional cytotoxic agents which act through a DNA-alkylating mechanism are relatively non-specific, resulting in a small therapeutic window and thus limiting their effectiveness. In this study, we evaluate a panel of 24 non-alkylating Strathclyde Minor Groove Binders (S-MGBs), including 14 novel...

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Vydáno v:Medchemcomm
Hlavní autoři: Nichol, Ryan J. O., Khalaf, Abedawn I., Sooda, Kartheek, Hussain, Omar, Griffiths, Hollie B. S., Phillips, Roger, Javid, Farideh A., Suckling, Colin J., Allison, Simon J., Scott, Fraser J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2019
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478159/
https://ncbi.nlm.nih.gov/pubmed/32952999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00268e
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