Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and (32)P-postlabelling

Benzo[a]pyrene (BaP) is a widespread environmental carcinogen activated by cytochrome P450 (P450) enzymes. In Hepatic P450 Reductase Null (HRN) and Reductase Conditional Null (RCN) mice, P450 oxidoreductase (Por) is deleted specifically in hepatocytes, resulting in the loss of essentially all hepati...

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Detalhes bibliográficos
Publicado no:Toxicol Lett
Main Authors: Arlt, Volker M., Poirier, Miriam C., Sykes, Sarah E., John, Kaarthik, Moserova, Michaela, Stiborova, Marie, Wolf, C. Roland, Henderson, Colin J., Phillips, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477777/
https://ncbi.nlm.nih.gov/pubmed/22759596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2012.06.016
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