Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

PURPOSE: Treatment failure from drug resistance is the primary reason for relapse in acute lymphoblastic leukemia. Improving outcomes by targeting mechanisms of drug resistance is a potential solution. EXPERIMENTAL DESIGN: We report results investigating the epigenetic modulators decitabine and vori...

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Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Burke, Michael J., Kostadinov, Rumen, Sposto, Richard, Gore, Lia, Kelley, Shannon, Rabik, Cara, Trepel, Jane, Lee, Min-Jung, Yuno, Akira, Lee, Sunmin, Bhojwani, Deepa, Jeha, Sima C., Chang, Bill H., Sulis, Maria Luisa, Hermiston, Michelle L., Gaynon, Paul S., Huynh, Van, Verma, Anupam, Gardner, Rebecca A., Heym, Kenneth M., Dennis, Robyn M., Ziegler, David S., Laetsch, Theodore W., Oesterheld, Javier E., DuBois, Steven G., Pollard, Jessica A., Glade-Bender, Julia, Cooper, Todd M., Kaplan, Joel A., Farooqi, Midhat, Yoo, Byunggil, Guest, Erin, Wayne, Alan S., Brown, Patrick
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477726/
https://ncbi.nlm.nih.gov/pubmed/31969338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1251
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