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Intrinsically disordered linkers control tethered kinases via effective concentration
Kinase specificity is crucial to the fidelity of signaling pathways, yet many pathways use the same kinases to achieve widely different effects. Specificity arises in part from the enzymatic domain but also from the physical tethering of kinases to their substrates. Such tethering can occur via prot...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474599/ https://ncbi.nlm.nih.gov/pubmed/32817491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006382117 |
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