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Intrinsically disordered linkers control tethered kinases via effective concentration
Kinase specificity is crucial to the fidelity of signaling pathways, yet many pathways use the same kinases to achieve widely different effects. Specificity arises in part from the enzymatic domain but also from the physical tethering of kinases to their substrates. Such tethering can occur via prot...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474599/ https://ncbi.nlm.nih.gov/pubmed/32817491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006382117 |
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