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Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

Phase transitions of linear multivalent proteins control the reversible formation of many intracellular membraneless bodies. Specific non-covalent crosslinks involving domains/motifs lead to system-spanning networks referred to as gels. Gelation transitions can occur with or without phase separation...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Harmon, Tyler S, Holehouse, Alex S, Rosen, Michael K, Pappu, Rohit V
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703641/
https://ncbi.nlm.nih.gov/pubmed/29091028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30294
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