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Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

The organization of membranes, the cytosol, and the nucleus of eukaryotic cells can be controlled through phase separation of lipids, proteins, and nucleic acids. Collective interactions of multivalent molecules mediated by modular binding domains can induce gelation and phase separation in several...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Banjade, Sudeep, Wu, Qiong, Mittal, Anuradha, Peeples, William B., Pappu, Rohit V., Rosen, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664304/
https://ncbi.nlm.nih.gov/pubmed/26553976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508778112
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