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Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
Liquid-liquid phase separation, driven by collective interactions among multivalent and intrinsically disordered proteins, is thought to mediate the formation of membrane-less organelles in cells. Using parallel cellular and in vitro assays we show that the Nephrin intracellular domain (NICD), a dis...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4973464/ https://ncbi.nlm.nih.gov/pubmed/27392146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.042 |
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