Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

Liquid-liquid phase separation, driven by collective interactions among multivalent and intrinsically disordered proteins, is thought to mediate the formation of membrane-less organelles in cells. Using parallel cellular and in vitro assays we show that the Nephrin intracellular domain (NICD), a dis...

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Udgivet i:Mol Cell
Main Authors: Pak, Chi W., Kosno, Martyna, Holehouse, Alex S., Padrick, Shae B., Mittal, Anuradha, Ali, Rustam, Yunus, Ali A., Liu, David R., Pappu, Rohit V., Rosen, Michael K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973464/
https://ncbi.nlm.nih.gov/pubmed/27392146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.042
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