Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

Dishevelled (DVL) is a key scaffolding protein and a branching point in Wnt signaling pathways. Here, we present conclusive evidence that DVL regulates the centrosomal cycle. We demonstrate that DVL dishevelled and axin (DIX) domain, but not DIX domain-mediated multimerization, is essential for DVL’...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cervenka, Igor, Valnohova, Jana, Bernatik, Ondrej, Harnos, Jakub, Radsetoulal, Matej, Sedova, Katerina, Hanakova, Katerina, Potesil, David, Sedlackova, Miroslava, Salasova, Alena, Steinhart, Zachary, Angers, Stephane, Schulte, Gunnar, Hampl, Ales, Zdrahal, Zbynek, Bryja, Vitezslav
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995965/
https://ncbi.nlm.nih.gov/pubmed/27486244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608783113
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