Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts

Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β (TGF-β), are central to its pathogenesis. Protein tyrosine phosphatase-α (PTPα) has emerged as a key regulato...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Aschner, Yael, Nelson, Meghan, Brenner, Matthew, Roybal, Helen, Beke, Keriann, Meador, Carly, Foster, Daniel, Correll, Kelly A., Reynolds, Paul R., Anderson, Kelsey, Redente, Elizabeth F., Matsuda, Jennifer, Riches, David W. H., Groshong, Steve D., Pozzi, Ambra, Sap, Jan, Wang, Qin, Rajshankar, Dhaarmini, McCulloch, Christopher A. G., Zemans, Rachel L., Downey, Gregory P.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473933/
https://ncbi.nlm.nih.gov/pubmed/32491951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00235.2019
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