Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts

Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β (TGF-β), are central to its pathogenesis. Protein tyrosine phosphatase-α (PTPα) has emerged as a key regulato...

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Publicado en:Am J Physiol Lung Cell Mol Physiol
Autores principales: Aschner, Yael, Nelson, Meghan, Brenner, Matthew, Roybal, Helen, Beke, Keriann, Meador, Carly, Foster, Daniel, Correll, Kelly A., Reynolds, Paul R., Anderson, Kelsey, Redente, Elizabeth F., Matsuda, Jennifer, Riches, David W. H., Groshong, Steve D., Pozzi, Ambra, Sap, Jan, Wang, Qin, Rajshankar, Dhaarmini, McCulloch, Christopher A. G., Zemans, Rachel L., Downey, Gregory P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473933/
https://ncbi.nlm.nih.gov/pubmed/32491951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00235.2019
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