Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts

Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β (TGF-β), are central to its pathogenesis. Protein tyrosine phosphatase-α (PTPα) has emerged as a key regulato...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Aschner, Yael, Nelson, Meghan, Brenner, Matthew, Roybal, Helen, Beke, Keriann, Meador, Carly, Foster, Daniel, Correll, Kelly A., Reynolds, Paul R., Anderson, Kelsey, Redente, Elizabeth F., Matsuda, Jennifer, Riches, David W. H., Groshong, Steve D., Pozzi, Ambra, Sap, Jan, Wang, Qin, Rajshankar, Dhaarmini, McCulloch, Christopher A. G., Zemans, Rachel L., Downey, Gregory P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473933/
https://ncbi.nlm.nih.gov/pubmed/32491951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00235.2019
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