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Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences

All tRNAs are extensively modified, and modification deficiency often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae, lack of any of several tRNA body modifications results in rapid tRNA decay (RTD) of certain m...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: De Zoysa, Thareendra, Phizicky, Eric M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473580/
https://ncbi.nlm.nih.gov/pubmed/32841241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008893
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