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Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways
T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the mechanism by which T cells develop this phenotype in solid tumors is needed. Here, hypoxia, a feature of the tumor microenvironment, causes T cell exhaustion (T(Exh)) by inducing a mitochondrial defect. Upon...
Zapisane w:
| Wydane w: | Front Immunol |
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| Główni autorzy: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7472844/ https://ncbi.nlm.nih.gov/pubmed/32973789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01906 |
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