Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the mechanism by which T cells develop this phenotype in solid tumors is needed. Here, hypoxia, a feature of the tumor microenvironment, causes T cell exhaustion (T(Exh)) by inducing a mitochondrial defect. Upon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Liu, Yi-Na, Yang, Jie-Feng, Huang, Dai-Jia, Ni, Huan-He, Zhang, Chuan-Xia, Zhang, Lin, He, Jia, Gu, Jia-Mei, Chen, Hong-Xia, Mai, Hai-Qiang, Chen, Qiu-Yan, Zhang, Xiao-Shi, Gao, Song, Li, Jiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472844/
https://ncbi.nlm.nih.gov/pubmed/32973789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01906
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