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T-cell exhaustion in the tumor microenvironment

T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to th...

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Bibliografski detalji
Izdano u:Cell Death Dis
Glavni autori: Jiang, Y, Li, Y, Zhu, B
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669840/
https://ncbi.nlm.nih.gov/pubmed/26086965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.162
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