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T-cell exhaustion in the tumor microenvironment
T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to th...
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| Udgivet i: | Cell Death Dis |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4669840/ https://ncbi.nlm.nih.gov/pubmed/26086965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.162 |
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