PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1(+)CD38(hi) cells and anti-PD-1 resistance

Understanding resistance to antibody to programmed cell death protein 1 (PD-1; anti-PD-1) is crucial for the development of reversal strategies. In anti-PD-1-resistant models, simultaneous anti-PD-1 and vaccine therapy reversed resistance, while PD-1 blockade before antigen priming abolished therape...

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Publicado no:Nat Immunol
Main Authors: Verma, Vivek, Shrimali, Rajeev K, Ahmad, Shamim, Dai, Winjie, Wang, Hua, Lu, Sumin, Nandre, Rahul, Gaur, Pankaj, Lopez, Jose, Sade-Feldman, Moshe, Yizhak, Keren, Bjorgaard, Stacey L., Flaherty, Keith T., Wargo, Jennifer A., Boland, Genevieve M., Sullivan, Ryan J., Getz, Gad, Hammond, Scott A., Tan, Ming, Qi, Jingjing, Wong, Phillip, Merghoub, Taha, Wolchok, Jedd, Hacohen, Nir, Janik, John E., Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472661/
https://ncbi.nlm.nih.gov/pubmed/31358999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0441-y
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