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PD-L1 (B7-H1) and PD-1 Pathway Blockade for Cancer Therapy: Mechanisms, Response Biomarkers and Combinations

PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has elicited durable anti-tumor responses and long-term remissions in a subset of patients with a broad spectrum of cancers. How to improve, widen, and predict the clinical response to anti-PD therapy is a central theme in the fi...

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Библиографические подробности
Опубликовано в: :Sci Transl Med
Главные авторы: Zou, Weiping, Wolchok, Jedd D., Chen, Lieping
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859220/
https://ncbi.nlm.nih.gov/pubmed/26936508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad7118
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